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Updated: Feb 15, 2026

In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
[Development of en face optical coherence tomography and its application in ocular fundus diseases]
1Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai 200031, China.
Abstract:
Optical coherence tomography (OCT) is able to obtain the cross-sectional image of the fundus noninvasively and quickly. The cross-sectional image in vivo almost matches the histological section of the retina. OCT has become the most important imaging tool in ophthalmology. Based on the latest OCT technology, en face OCT is a new imaging technique that reveals the structure of retinal and choroidal sections approximately paralleled to the retina surface. Compared to the conventional OCT, en face OCT provides more comprehensive information and makes more accurate diagnosis and assessment of the prognosis. En face OCT is widely used in ocular fundus diseases, such as macular epiretinal membrane, macular hole, macular edema, age-related macular degeneration and retinal vascular disease, glaucoma and neuro-ophthalmology. This article reviews the related concepts, principles and clinical applications of en face OCT. (Chin J Ophthalmol, 2017, 53: 956-960).
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