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Terbinafine hydrochloride nail lacquer for the management of onychomycosis: formulation, characterization and in
1Department of Pharmaceutical Sciences, Pharmaceutics Division, Punjabi University, Patiala, 147002, India.
Aim:
The present investigation's intention was to develop an optimized nail lacquer (NL) for the management of onychomycosis.
Materials & Methods:
The NL was optimized statistically adopting 32 full factorial design having different polymer ratios and solvent ratios. The formulations were assessed for drug permeation drying time and peak adhesive strength of the film. Characterization was done using techniques including attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray diffraction (XRD), etc.
Results & Conclusion:
The formulation that had 1:1 polymer ratio and 80:20 solvent ratio was chosen as the optimized formulation. In vitro permeation studies showed better penetration (∼3.25-fold) as well as retention (∼11-fold) of the optimized NL formulation in the animal hoof as compared with the commercial formulation. The findings of in vitro and ex vivo studies elucidated the potential of the optimized formulation. [Formula: see text].
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