Chinese Cervicocephalic artery dissection study (CCADS): rationale and protocol for a multicenter prospective cohort...

Area of Science:

• Neurology
• Vascular Medicine
• Epidemiology

Background:

• Cervicocephalic artery dissection (CAD) is a significant cause of stroke, particularly in younger populations.
• Recent research suggests CAD is a complex group of diseases with varied causes, presentations, and outcomes.
• Understanding unique characteristics of CAD in Chinese patients is crucial, as they may differ from Western populations.

Purpose of the Study:

• To explore the epidemiology, risk factors, clinical and radiological features, diagnosis, and prognosis of CAD in Chinese patients.
• To conduct an integral study of various CAD types to enhance understanding of this condition.
• To establish the Chinese Cervicocephalic Artery Dissection Study (CCADS) for comprehensive CAD research in China.

Main Methods:

• A multicenter prospective cohort study enrolling patients aged 18 years and older with recent CAD (<14 days onset).
• Collection of baseline clinical data, laboratory tests, and imaging studies within 3 days of admission.
• Follow-up assessments at discharge, 3, 6, and 12 months, including modified Rankin Scale (mRS), cerebrovascular events, and CAD evolution. Blood samples collected at baseline and follow-up points.

Main Results:

• This section is not available in the provided abstract.

Conclusions:

• The CCADS aims to provide comprehensive data on CAD in the Chinese population by integrating epidemiological, clinical, and radiological information.
• Advanced imaging, biomarker collection, and novel treatment strategy assessments will be utilized.
• Findings are expected to contribute to the prevention and treatment strategies for stroke caused by CAD in young individuals.