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Genomics of Corynebacterium striatum, an emerging multidrug-resistant pathogen of immunocompromised patients

K Nudel1, X Zhao1, S Basu2

  • 1Massachusetts Host-Microbiome Center, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|January 13, 2018
PubMed
Abstract

Insights

Genomic analysis revealed that multidrug-resistant Corynebacterium striatum can spread clonally in hospitals. Novel mobile genetic elements facilitate the transmission of multiple antibiotic resistance genes, complicating treatment for vulnerable patients.

Area of Science:

  • Medical Microbiology
  • Genomics
  • Infectious Diseases

Background:

  • Corynebacterium striatum is an emerging multidrug-resistant (MDR) pathogen.
  • It primarily affects immunocompromised and chronically ill patients, particularly those with respiratory conditions.

Purpose of the Study:

  • To conduct a detailed genomic analysis of disease-causing C. striatum.
  • To identify the genomic drivers of antimicrobial resistance and gene transmission.

Main Methods:

  • Prospective pathogen genomics program identified seven MDR C. striatum infections.
  • Whole genome sequencing was employed to assess clonal relationships and resistance mechanisms.
  • MALDI-TOF analyses were used for improved strain identification.

Main Results:

  • A cluster of three C. striatum infections was linked to common exposures in lung transplant patients.
  • Genomic analysis identified insertion sequences (IS3504, ISCg9a-like) mobilizing resistance genes.
  • Seven mobilizable resistance genes were found in a common region, enabling potential spread of resistance to multiple antibiotic classes.

Conclusions:

  • MDR C. striatum exhibits clonal spread within and between healthcare facilities.
  • Novel mobile genetic elements facilitate the mobilization of multiple drug resistance genes.
  • These findings complicate treatment strategies for infections in immunocompromised populations.
Keywords:
Corynebacterium striatumImmunocompromisedMatrix-assisted linear desorption/ionization-time-of-flight mass spectrometryMultidrug-resistant pathogensWhole genome sequencing

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