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Ligandomics: a paradigm shift in biological drug discovery
Wei Li1, Iok-Hou Pang2, Mario Thiego F Pacheco1
1Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, FL, USA.
Drug Discovery Today
|January 13, 2018
Summary
Ligandomics offers a new approach to drug discovery by systematically mapping cellular ligands. This method aids in developing highly effective biologics with fewer side effects, addressing challenges in pharmaceutical research and development.
Area of Science:
- Biochemistry
- Pharmacology
- Drug Discovery
Background:
- Pharmaceutical research and development (R&D) for small-molecule drugs faces declining productivity.
- There is a strategic shift towards biologics targeting cell surface or secreted proteins.
- Receptors and ligands are critical targets in drug development.
Purpose of the Study:
- To introduce ligandomics as an emerging technology for drug discovery.
- To highlight the advantages of targeting disease-selective cellular ligands.
- To address the bottleneck in target discovery for biologics development.
Main Methods:
- Ligandomics systematically maps disease-selective cellular ligands.
- This approach does not require molecular probes for ligand identification.
- Focuses on identifying ligands for biologics development.
Main Results:
- Ligandomics enables systematic mapping of disease-selective ligands.
- Biologics targeting these ligands demonstrate high efficacy and safety.
- Potential for wide therapeutic indices and low safety-related attrition.
Conclusions:
- Ligandomics represents a paradigm shift in drug discovery.
- It offers a solution to the target discovery bottleneck for biologics.
- Facilitates the development of more effective and safer therapeutics.
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