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Hemorheological effects of amlodipine in spontaneously hypertensive rats
Aleksandr Y Shamanaev1, Oleg I Aliev1, Anna M Anishchenko1
1Department of Pharmacology, E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.
Objectives:
The effect of course administration of amlodipine on whole blood viscosity and on macro- and microrheological parameters was evaluated.
Materials And Methods:
SHRs were treated intragastrically with amlodipine at a dose of 10 mg/kg for 6 weeks. After finishing the course, hemodynamic and hemorheological parameters were measured.
Results:
The antihypertensive treatment with amlodipine resulted in a significant decrease in mean blood pressure by 29% and left ventricular to body weight mass index by 7%. Nevertheless, BV tended to increase. The administration of amlodipine had no effect on PV, plasma fibrinogen concentration, RBC aggregation, and RBC deformability, but hematocrit was higher (by 6%) than it was in control group.
Conclusions:
These results demonstrate that amlodipine has no positive hemorheological improvements when administered to SHRs.
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