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Age-Related Decrease in Male Extra-Striatal Adenosine A1 Receptors Measured Using11C-MPDX PET.

Masahiro Mishina1,2,3, Yuichi Kimura2,4, Muneyuki Sakata2

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This study found that adenosine A1 receptors (A1Rs) decrease in density in the aging human brain, specifically in the thalamus and cerebral cortices. Positron emission tomography (PET) imaging with 11C-MPDX confirmed this age-related decline in A1R distribution.

Keywords:
adenosine A1 receptoragingcerebral cortexhumanspositron emission tomographythalamus

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Area of Science:

  • Neuroscience
  • Radiochemistry
  • Gerontology

Background:

  • Adenosine A1 receptors (A1Rs) are widespread in the human brain.
  • Previous research indicated reduced A1R binding in aged rat striata.
  • Age-related changes in human A1R density were previously observed in the striatum.

Purpose of the Study:

  • To investigate age-related changes in A1R density within the human thalamus and cerebral cortices.
  • To utilize positron emission tomography (PET) with the novel ligand 11C-MPDX for this investigation.

Main Methods:

  • Recruited young and elderly healthy male volunteers.
  • Administered 11C-MPDX and conducted dynamic PET scans for 60 minutes.
  • Calculated binding potential (BPND) in the thalamus and various cortical regions using graphical analysis with the cerebellum as a reference.

Main Results:

  • A significant reduction in 11C-MPDX binding potential (BPND) was observed in elderly participants compared to young participants.
  • This age-related decrease was evident in the thalamus, frontal, temporal, occipital, and parietal cortices.
  • The findings confirm an age-dependent decline in A1R distribution in these brain regions.

Conclusions:

  • Adenosine A1 receptor density decreases with age in the human thalamus and cerebral cortices.
  • The PET ligand 11C-MPDX is effective for visualizing age-related changes in A1R distribution.
  • This research contributes to understanding neurobiological changes associated with aging.