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Updated: Feb 15, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
A facile one-pot synthesis of acrylated hyaluronic acid
Sigen A1, Qian Xu, Peter McMichael
1Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Ireland. wenxin.wang@ucd.ie dezhong.zhou@ucd.ie.
Abstract:
The synthesis of acrylated hyaluronic acid (HA-A) normally requires 2 to 3 steps of modification, needs laborious purification and also increases the risks of HA degradation. Here, we report that the conjugation of acrylate groups to hyaluronic acid can be successfully achieved via a new facile one-pot approach. Two types of new HA-A hydrogels (via chemical or UV crosslinking) were developed and applied for 3D cell encapsulation.
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