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Related Experiment Videos

[Melatonin].

M Fevre-Montange

    Presse Medicale (Paris, France : 1983)
    |September 21, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Melatonin, a hormone from the pineal gland, shows circadian rhythms and is linked to various diseases. Its exact role in humans remains unclear, despite potential as a biological marker.

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    Area of Science:

    • Endocrinology
    • Neuroscience
    • Chronobiology

    Background:

    • Melatonin, an indolamine synthesized in the pineal gland, is known as the 'epiphyseal hormone'.
    • It exhibits antigonadotropic, endocrine inhibitory, and anti-convulsive properties in animal models.
    • Recent advancements in assay methods allow for clinical data acquisition, though currently descriptive.

    Purpose of the Study:

    • To describe the clinical data on melatonin secretion patterns and its associations with various physiological and pathological conditions.
    • To explore the potential role of melatonin as a biological marker in diseases.

    Main Methods:

    • Analysis of clinical data on melatonin presence in body fluids (urine, blood, cerebrospinal fluid).
    • Observation of circadian secretion patterns and seasonal variations.

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  • Investigation of the adrenergic system's role in melatonin secretion.
  • Correlation of abnormal melatonin levels/rhythms with specific diseases.

    • Main Results:

    • Melatonin is present in multiple body fluids and secreted in circadian cycles (low day, high night).
    • Secretion shows seasonal variation and is influenced by the adrenergic system (beta-blockers inhibit nocturnal rise).
    • Abnormal melatonin concentrations/rhythms are observed in breast cancer, liver cirrhosis, Klinefelter's syndrome, Cushing's syndrome, haemochromatosis, and depressive syndromes.

    Conclusions:

    • Melatonin secretion follows distinct circadian and seasonal patterns, influenced by the adrenergic system.
    • Perturbations in melatonin secretion are associated with several diseases, including cancers and psychiatric disorders.
    • While melatonin shows potential as a biological marker, its precise physiological function in humans requires further elucidation.