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Changes in Iron Absorption After Roux-en-Y Gastric Bypass
Wendy Schijns1, Marjolein A P Ligthart2, Frits J Berends2
1Department of Surgery, Rijnstate Hospital, Postal number 1190, 6800, TA, Arnhem, The Netherlands. wschijns@rijnstate.nl.
Obesity Surgery
|January 13, 2018
Summary
Iron deficiency is common after Roux-en-Y gastric bypass (RYGB). Solubilized ferrous gluconate is better absorbed than ferrous fumarate tablets post-RYGB, making it the preferred iron supplement.
Area of Science:
- Bariatric Surgery
- Nutritional Science
- Gastroenterology
Background:
- Iron deficiency is a frequent complication following Roux-en-Y gastric bypass (RYGB).
- Optimal strategies for managing post-RYGB iron deficiency remain unclear.
Purpose of the Study:
- To compare iron absorption characteristics of two oral iron formulations after RYGB.
- To evaluate the impact of RYGB on the absorption of ferrous fumarate tablets versus ferrous gluconate solution.
Main Methods:
- 24 obese women undergoing RYGB were assessed for iron absorption.
- Participants received either ferrous fumarate tablets or ferrous gluconate solution pre- and post-surgery.
- Serum iron levels were monitored hourly for 9 hours post-supplementation.
Main Results:
- Pre-surgery, both iron supplements showed similar absorption.
- Post-RYGB, ferrous fumarate tablet absorption significantly decreased (P < 0.001).
- Ferrous gluconate solution absorption was not significantly affected by RYGB (P = 0.13).
Conclusions:
- Roux-en-Y gastric bypass impairs ferrous fumarate tablet absorption.
- Solubilized ferrous gluconate demonstrates better absorption post-RYGB.
- A solubilized iron supplement is recommended as the first-line choice after RYGB.
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