Dengue-Induced Hepatic Injury

Area of Science:

• * Tropical Medicine
• * Hepatology
• * Infectious Diseases

Background:

• * Dengue virus poses a significant global health burden, particularly in tropical areas.
• * Transmission occurs through Aedes mosquito vectors.
• * Hepatotoxicity is a known complication of dengue virus infection.

Purpose of the Study:

• * To review the pathogenesis of dengue-related liver dysfunction.
• * To outline the clinical manifestations and diagnostic approaches.
• * To discuss current treatment strategies for hepatic complications.

Main Methods:

• * Comprehensive literature review of studies on dengue and liver injury.
• * Analysis of pathogenesis, clinical presentation, and management protocols.
• * Synthesis of information on investigations and therapeutic interventions.

Main Results:

• * Dengue virus infection can lead to a spectrum of liver injury, from mild enzyme elevation to acute liver failure.
• * Hepatotoxicity is often under-recognized, especially in asymptomatic or mildly symptomatic cases.
• * Specific diagnostic markers and supportive care are crucial for managing dengue-related hepatic dysfunction.

Conclusions:

• * Dengue should be considered in the differential diagnosis of acute liver failure in endemic areas.
• * Understanding the hepatic manifestations is vital for timely diagnosis and management.
• * Further research into targeted therapies for dengue-induced liver injury is warranted.