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Updated: Feb 15, 2026

Evaluation of a Reliable Biomarker in a Cecal Ligation and Puncture-Induced Mouse Model of Sepsis
Published on: December 9, 2022
Syndecan-1 as a biomarker for sepsis survival after major abdominal surgery
Maximilian S Holzmann1, Martin S Winkler1, Mike S Strunden2
1Department of Anesthesiology, Center of Anesthesiology & Intensive Care, University Medical Center Hamburg-Eppendorf, Martinistr 52, 20246, Hamburg, Germany.
Aim:
Sepsis is a serious complication following surgery and identification of patients at risk is of high importance. Syndecan-1 (sSDC1) levels are known to be elevated during sepsis.
Materials & Methods:
Fifty-five patients scheduled for major abdominal surgery were prospectively included and sSDC1 concentrations were measured during hospital stay.
Results:
Patients with postoperative sepsis showed a continued increase of sSDC1 levels and exhibited higher median sSDC1 concentrations at day 1 compared with nonseptic patients 90.3 versus 16.5 ng/ml. A significant association of sSDC1 levels with the incidence of sepsis and death was demonstrated.
Conclusion:
This study identifies sSDC1 as potential biomarker for sepsis and survival after abdominal surgery.
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