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Updated: Feb 15, 2026
Granulocyte-dependent Autoantibody-induced Skin Blistering
Published on: October 12, 2012
Nail changes in autoimmune blistering disorders: A case-control study
Vaishnavi Gopal1, Manjunath Mala Shenoy1, Vishal Bejai1
1Department of Dermatology, Venereology and Leprosy, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, India.
Background:
Pemphigus and pemphigoid disorders produce blistering cutaneous lesions. Earlier case reports state that nail involvement is uncommon in these autoimmune blistering disorders.
Aims And Objectives:
To study nail changes in autoimmune blistering disorders.
Methods:
A case-control study was conducted where 40 cases and 40 controls were evaluated for nail changes.
Results:
Nail changes were seen in 72.5% of cases and 17.5% of controls. The most common nail findings were paronychia and onychorrhexis.
Limitations:
Small sample size; short study duration; nail biopsy could not be done.
Conclusion:
Our findings indicate that the inflammatory nature of the blistering cutaneous disease is often reflected conspicuously in the nails.
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