[Treatment of acne vulgaris with clindamycin phosphate in dermatologic practice]

In an open study, 34 male and 16 female patients suffering from mild up to severe acne vulgaris were treated with topical clindamycin-phosphate over a period of 8 weeks. In the course of treatment, 96% of the patients showed improvement. In 52% of the cases, at least 65% of the inflammatory eruptions faded or they disappeared altogether; 44% of the cases showed reduction of 30-65% of their lesions. Only 4% of the patients did not respond at all to the treatment. Separate study on the various degrees of severity of the disease revealed greater improvement of severe acne than with mild and moderate forms. On the basis of pathophysiology, these cases might be still more successfully treated by means of combined therapy with comedolytics.