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Updated: Feb 15, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Preventing cardiovascular disease in older adults: One size does not fit all
Ariela R Orkaby1,2, Oyere Onuma3, Saadia Qazi4,5
1VA Boston Healthcare System, Geriatric Research, Education, and Clinical Center (GRECC), Boston, MA, USA.
Insights
Identifying frailty is key for aging adults with cardiovascular disease. Early detection enables personalized risk assessment and tailored management of conditions like hypertension and diabetes.
Area of Science:
- Gerontology
- Cardiology
- Internal Medicine
Background:
- Frailty and cardiovascular disease (CVD) prevalence increase with age.
- These conditions are interconnected, impacting the aging population significantly.
Purpose of the Study:
- To highlight the importance of identifying frailty in older adults.
- To emphasize the role of frailty assessment in personalized cardiovascular care.
Main Methods:
- The study focuses on the conceptual link between frailty and CVD.
- It reviews current understanding of their co-occurrence and management implications.
Main Results:
- Frailty identification facilitates tailored cardiovascular risk prescriptions.
- Individualized management strategies for hypertension, hyperlipidemia, and diabetes can be developed.
Conclusions:
- Assessing frailty is crucial for optimizing cardiovascular health in the elderly.
- Personalized management plans based on frailty status improve patient outcomes.
Abstract:
Frailty and cardiovascular disease are highly interconnected and increase in prevalence with age. Identifying frailty allows for a personalized cardiovascular risk prescription and individualized management of hypertension, hyperlipidemia, diabetes, and lifestyle in the aging population.
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