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A Viral (Arc)hive for Metazoan Memory.

Nicholas F Parrish¹, Keizo Tomonaga²

¹Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.

|January 13, 2018

Summary

The neural protein Arc, crucial for synaptic plasticity, can form virus-like capsids. This allows Arc to transfer messenger RNA (mRNA) between brain cells, potentially impacting synaptic function.

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Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

Arc (Activity-Regulated Cytoskeleton-associated protein) is a key regulator of synaptic plasticity.
Arc possesses sequence homology to retrotransposon Gag genes, suggesting a shared evolutionary origin.

Purpose of the Study:

To investigate the retroviral-like capsid-forming ability of Arc.
To determine if Arc facilitates mRNA transmission between neurons.

Main Methods:

Analysis of Arc protein structure and self-assembly.
Cellular assays to track mRNA transfer mediated by Arc.

Main Results:

Arc demonstrates retroviral-like capsid formation.
Arc actively transports mRNA between cells in the nervous system.

Conclusions:

Arc's ability to form capsids and transfer mRNA provides a novel mechanism for intercellular communication in the brain.
This finding offers new insights into the molecular basis of synaptic plasticity and neuronal function.