Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Nucleosome02:33

The Nucleosome

19.1K
DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
19.1K
The Nucleosome02:33

The Nucleosome

5.2K
5.2K
The Nucleosome01:19

The Nucleosome

4.3K
Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
4.3K
Nucleosome Remodeling02:54

Nucleosome Remodeling

11.3K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.3K
The Nucleosome Core Particle02:10

The Nucleosome Core Particle

14.6K
Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
14.6K
Sequence Networks of Rotating Machines01:24

Sequence Networks of Rotating Machines

503
A Y-connected synchronous generator, grounded through a neutral impedance, is designed to produce balanced internal phase voltages with only positive-sequence components. The generator's sequence networks include a source voltage that is exclusively in the positive-sequence network. The sequence components of line-to-ground voltages at the generator terminals illustrate this configuration.
Zero-sequence current induces a voltage drop across the generator's neutral impedance and other...
503

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differentially private data augmentation via LLM generation with discriminative and distribution-aligned filtering.

Neural networks : the official journal of the International Neural Network Society·2026
Same author

Multi-omics data reveal causal associations of cellular senescence-related genes in rheumatoid arthritis: A summary-data-based Mendelian randomization and co-localization analysis.

Medicine·2026
Same author

PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications.

Journal of translational medicine·2026
Same author

Bionic platelet membrane-coated rutin nanoparticles attenuate ulcerative colitis by suppressing platelet-mediated macrophage inflammation.

Drug delivery and translational research·2025
Same author

Systemic analysis of rural teacher attrition in china: a hybrid DEMATEL-ISM approach to multidimensional drivers and policy implications.

Scientific reports·2025
Same author

The Role of WNT5A-mediated proteomic and phosphoproteomic regulatory networks in rheumatoid arthritis.

Immunobiology·2025

Related Experiment Video

Updated: Feb 15, 2026

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
10:40

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA

Published on: September 10, 2013

23.1K

LeNup: learning nucleosome positioning from DNA sequences with improved convolutional neural networks.

Juhua Zhang1,2, Wenbo Peng1, Lei Wang1

  • 1Department of Biomedical Engineering.

Bioinformatics (Oxford, England)
|January 13, 2018
PubMed
Summary

We developed LeNup, a novel convolutional neural network (CNN), to accurately predict nucleosome positioning in eukaryotic genomes. This machine learning tool enhances understanding of genome regulation and accessibility.

More Related Videos

Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications
03:31

Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications

Published on: December 15, 2023

1.1K
Generation of Native Chromatin Immunoprecipitation Sequencing Libraries for Nucleosome Density Analysis
10:05

Generation of Native Chromatin Immunoprecipitation Sequencing Libraries for Nucleosome Density Analysis

Published on: December 12, 2017

22.9K

Related Experiment Videos

Last Updated: Feb 15, 2026

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
10:40

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA

Published on: September 10, 2013

23.1K
Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications
03:31

Author Spotlight: Enhancement of Salient Object Detection for Smart Grid Applications

Published on: December 15, 2023

1.1K
Generation of Native Chromatin Immunoprecipitation Sequencing Libraries for Nucleosome Density Analysis
10:05

Generation of Native Chromatin Immunoprecipitation Sequencing Libraries for Nucleosome Density Analysis

Published on: December 12, 2017

22.9K

Area of Science:

  • Genomics
  • Computational Biology
  • Bioinformatics

Background:

  • Nucleosome positioning is crucial for genome organization and regulating gene transcription.
  • Existing methods for analyzing nucleosome positioning data have limitations in fully deciphering its complexity.

Purpose of the Study:

  • To develop a novel computational tool for predicting nucleosome positioning.
  • To improve the understanding of eukaryotic nucleosome positioning using machine learning.

Main Methods:

  • Developed a novel convolutional neural network (CNN) incorporating Inception-like networks and a gating mechanism.
  • Trained the CNN model, named LeNup, on four benchmark datasets for nucleosome positioning prediction.
  • Applied LeNup to predict nucleosome positioning in Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, and Saccharomyces cerevisiae.

Main Results:

  • LeNup demonstrated higher predictive accuracy compared to existing methods.
  • The CNN architecture effectively captures multiple patterns and long-term associations in DNA sequences relevant to nucleosome positioning.

Conclusions:

  • LeNup provides a powerful and accurate method for predicting nucleosome positioning across diverse eukaryotic species.
  • The developed tool advances the analysis of genome accessibility and transcription regulation.