Related Experiment Video
Updated: Feb 15, 2026

The Benthic Exchange of O2, N2 and Dissolved Nutrients Using Small Core Incubations
Published on: August 3, 2016
Oral Bifidobacterium longum expressing GLP-2 improves nutrient assimilation and nutritional homeostasis in mice
Qian Zhang1, Mengge Liu1, Shiyu Li2
1Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou, 510632, China.
Abstract:
Bifidobacterium has been developed for the oral delivery of peptides and has the added beneficial effect on our bodies through its probiotic properties. Here, we utilize Bifidobacterium as a delivery system to orally deliver Glucagon like peptide-2 (GLP-2). We constructed vector derived from pET-31b(+) to construct a Bifidobacterium longum expressing GLP-2. We then determined the bioactivity of recombinant Bifidobacterium in Caco-2 cells. Finally, we quantified newly synthesized ApoB48 and chylomicron production in mice infused with exogenous GLP-2 or Bifidobacterium expressing GLP-2. Results based on secretion of the triglyceride (TG)-rich lipoprotein (TRL)-ApoB48 and secretion of chylomicron revealed that recombinant Bifidobacterium was efficient in treating intestinal dysfunction,suggesting an alternative way to use Bifidobacterium as a delivery system to deliver GLP-2 for gastrointestinal nutrition coordination.
More Related Videos
Related Concept Videos
The Roles of Bacteria and Fungi in Plant Nutrition
Key Elements for Plant Nutrition
What is Homeostasis?
Sulfur Assimilation
pH Homeostasis
Respiratory...
Inorganic Nitrogen Assimilation

