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Updated: Feb 15, 2026

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
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Novel expression of CD11b in epithelial ovarian cancer: Potential therapeutic target

Ghassan M Saed1, Nicole M Fletcher1, Michael P Diamond2

  • 1Department of Obstetrics and Gynecology, The C.S. Mott Center for Human Growth and Development, Wayne State University School of Medicine, 275 E Hancock St, Detroit, MI 48201, United States.

Gynecologic Oncology
|January 14, 2018
PubMed
Abstract

Insights

This study reveals CD11b as a novel target in ovarian cancer. Targeting CD11b with a monoclonal antibody selectively kills ovarian cancer cells, even chemoresistant ones, and enhances chemotherapy efficacy.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Epithelial ovarian cancer (EOC) remains a significant health challenge.
  • Identifying novel therapeutic targets is crucial for improving patient outcomes.

Purpose of the Study:

  • To investigate the expression of CD11b in ovarian cancer.
  • To evaluate the therapeutic potential of targeting CD11b with a monoclonal antibody in EOC.

Main Methods:

  • CD11b expression analysis using immunofluorescence and flow cytometry.
  • Cytotoxicity and drug synergism assays (MTT assay) in various cell lines.
  • In vivo efficacy assessment in an ovarian cancer xenograft model.

Main Results:

  • CD11b is unexpectedly expressed in EOC cells and tissues, but not normal cells.
  • Monoclonal antibody targeting of CD11b demonstrated selective cytotoxicity against EOC cells.
  • Significant synergistic effects were observed when combining the CD11b antibody with cisplatin or docetaxel.
  • In vivo studies confirmed the anti-tumorigenic effect of the CD11b antibody.

Conclusions:

  • CD11b represents a novel and selective therapeutic target for ovarian cancer.
  • Targeting CD11b offers a promising strategy to overcome chemoresistance and enhance treatment efficacy in EOC.
Keywords:
ApoptosisCD11bCD11b antibodyCytotoxicityMyeloperoxidaseSurvival mechanism

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