Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:42

The Extracellular Matrix

89.6K
Overview
89.6K
The Extracellular Matrix01:29

The Extracellular Matrix

12.5K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
12.5K
Extracellular Matrix01:26

Extracellular Matrix

5.7K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
5.7K
Binet's Contribution to Measures of Intelligence01:23

Binet's Contribution to Measures of Intelligence

1.8K
Alfred Binet, along with his student Théophile Simon, was tasked by the French Ministry of Education in 1904 to create a method for identifying students who struggled to learn through conventional classroom instruction. This initiative aimed to address overcrowding by placing such students in specialized schools. Binet and Simon developed an intelligence test comprising 30 tasks, ranging from simple commands, like touching one's nose or ear, to more complex tasks, such as drawing...
1.8K
Wechsler's Contribution to Measures of Intelligence01:23

Wechsler's Contribution to Measures of Intelligence

2.2K
David Wechsler, a psychologist who worked with World War I veterans, developed a significant IQ test in 1939 called the Wechsler-Bellevue Intelligence Scale. This test was innovative because it combined several subtests that measured both verbal and nonverbal skills, reflecting Wechsler's belief that intelligence is a global capacity involving purposeful action, rational thinking, and effective interaction with the environment. This test later evolved into the Wechsler Adult Intelligence...
2.2K
The Bone Matrix01:18

The Bone Matrix

5.9K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When proteases reshape barriers: Basement membrane remodelling in development, wound healing and tumour progression.

The FEBS journal·2026
Same author

Human mammary 3D spheroid models uncover the role of filopodia in breaching the basement membrane to facilitate invasion.

Matrix biology : journal of the International Society for Matrix Biology·2025
Same author

Self-assembled peptide RADA16 hydrogel supports wound epithelialization by a laminin-332-dependent binding mechanism.

Acta biomaterialia·2025
Same author

Lipidized LL37-loaded PLGA nanocarriers: Bioengineered peptide delivery systems for enhanced wound healing.

International journal of pharmaceutics·2025
Same author

Bioderived Green Algae Metabolite as a Latent Cross-Linking Agent for Protein-Based Hydrogels with High Potential for Skin Repair Applications.

ACS applied bio materials·2025
Same author

Dermal stiffness governs the topography of the epidermis and the underlying basement membrane in young and old human skin.

Aging cell·2024

Related Experiment Video

Updated: Feb 15, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.6K

Extracellular matrix contribution to skin wound re-epithelialization.

Patricia Rousselle1, Marine Montmasson1, Cécile Garnier1

  • 1Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique, UMR 5305, CNRS - Université Lyon 1, Institut de Biologie et Chimie des Protéines, SFR BioSciences Gerland-Lyon Sud, 7 passage du Vercors, F-69367, France.

Matrix Biology : Journal of the International Society for Matrix Biology
|January 14, 2018
PubMed
Summary

Skin barrier function relies on cellular integrity and repair post-injury. This study examines how extracellular matrix proteins influence epidermal regeneration during the complex wound healing process in mammals.

Keywords:
Basement membraneEpidermal regenerationExtracellular matrixKeratinocyteLamininRe-epithelializationWound healing

More Related Videos

Demonstration of the Rat Ischemic Skin Wound Model
08:35

Demonstration of the Rat Ischemic Skin Wound Model

Published on: April 1, 2015

22.7K
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

16.5K

Related Experiment Videos

Last Updated: Feb 15, 2026

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice
08:09

Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice

Published on: March 24, 2017

8.6K
Demonstration of the Rat Ischemic Skin Wound Model
08:35

Demonstration of the Rat Ischemic Skin Wound Model

Published on: April 1, 2015

22.7K
Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
09:43

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

16.5K

Area of Science:

  • Dermatology and regenerative medicine.
  • Cellular biology and tissue repair mechanisms.

Background:

  • Skin acts as a crucial barrier, maintained by cellular continuity and integrity.
  • Cutaneous wound healing is a complex, multi-stage process involving inflammation, re-epithelialization, and tissue remodeling.
  • Epidermal regeneration is vital for restoring skin integrity after injury.

Purpose of the Study:

  • To investigate the role of extracellular matrix (ECM) proteins in epidermal regeneration during wound healing.
  • To understand the signaling cues and cellular processes involved in skin repair.

Main Methods:

  • Focus on the involvement of extracellular matrix proteins.
  • Analysis of signaling cues, cellular receptors, and matrix metalloproteinases.

Main Results:

  • Extracellular matrix proteins significantly impact epidermal regeneration.
  • Multiple signaling pathways and cellular processes coordinate skin repair.

Conclusions:

  • Extracellular matrix proteins are key modulators of epidermal regeneration during wound healing.
  • Understanding ECM's role can lead to improved therapeutic strategies for skin repair.