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Related Concept Videos

Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer Prevention02:59

Cancer Prevention

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Related Experiment Video

Updated: Feb 15, 2026

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
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Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

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Prostate cancer-associated lncRNAs.

Yuichi Mitobe1, Ken-Ichi Takayama2, Kuniko Horie-Inoue1

  • 1Division of Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Saitama, Japan.

Cancer Letters
|January 14, 2018
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (LncRNAs) are functional transcripts crucial in biological processes. This review highlights key lncRNAs in prostate cancer development and their therapeutic potential.

Keywords:
Androgen receptorCastration-resistant prostate cancerLong non-coding RNAProstate cancerRNA biology

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Last Updated: Feb 15, 2026

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Area of Science:

  • Molecular Biology
  • Genomics
  • Oncology

Background:

  • Long non-coding RNAs (LncRNAs) are RNA transcripts over 200 nucleotides that do not code for proteins.
  • High-throughput sequencing has revealed lncRNAs' significant roles in biological and pathological processes.
  • Prostate cancer pathophysiology involves specific lncRNAs, often linked to androgen receptor signaling.

Purpose of the Study:

  • To review the current understanding of prostate cancer-associated lncRNAs.
  • To discuss the historical context and future directions for lncRNA research in prostate cancer.
  • To highlight the role of lncRNAs in prostate cancer development and progression.

Main Methods:

  • Literature review of recent advances in lncRNA research.
  • Analysis of high-throughput sequencing data identifying functional lncRNAs.
  • Focus on lncRNAs implicated in prostate cancer biology.

Main Results:

  • Numerous lncRNAs have been identified as functional transcripts.
  • Several key lncRNAs play critical roles in prostate cancer pathophysiology.
  • LncRNAs are involved in androgen-regulated pathways in prostate cancer.

Conclusions:

  • LncRNAs are emerging as important regulators in prostate cancer.
  • Understanding these lncRNAs offers new avenues for prostate cancer diagnosis and treatment.
  • Future research should focus on the therapeutic potential of lncRNAs in prostate cancer.