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Updated: Feb 15, 2026

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Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party

Gerrit J Schuurhuis1, Michael Heuser2, Sylvie Freeman3

  • 1Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands.

Blood
|January 14, 2018
PubMed

Insights

Measurable residual disease (MRD) is a key prognostic indicator in acute myeloid leukemia (AML). Standardizing MRD measurement is crucial for improving risk stratification and treatment planning in AML patients.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Diagnostics

Background:

  • Measurable residual disease (MRD) serves as an independent prognostic indicator in acute myeloid leukemia (AML).
  • MRD assessment aids in risk stratification and treatment planning alongside diagnostic clinical, cytogenetic, and molecular data.
  • Current MRD evaluation methods (flow cytometry, molecular assays) lack standardization, posing challenges for clinical application.

Purpose of the Study:

  • To identify critical clinical and scientific issues related to MRD measurement and application in AML.
  • To establish consensus on these issues among experts.
  • To develop guidelines for the current and future clinical use of MRD in AML.

Main Methods:

  • Convened a dedicated MRD Working Party under the European LeukemiaNet.
  • Conducted 4 meetings over 2 years involving 24 faculty members.
  • Included experts in AML hematopathology, molecular diagnostics, clinical trials, and clinical medicine from Europe and the US.

Main Results:

  • Identified key challenges in the standardization of MRD measurement techniques.
  • Achieved consensus on critical aspects of MRD assessment and clinical utility.
  • Developed comprehensive guidelines for MRD's role in AML management.

Conclusions:

  • Standardization of MRD measurement is essential for its reliable use in AML clinical practice.
  • Established guidelines provide a framework for consistent MRD application in risk stratification and treatment decisions.
  • Further research and collaboration are needed to refine and implement standardized MRD protocols in AML.

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