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Updated: Feb 15, 2026

Evaluation of the In vivo Antitumor Activity of Polyanhydride IL-1α Nanoparticles
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HIF2α Antagonism Has Antitumor Activity in Advanced ccRCC

    Cancer Discovery
    |January 14, 2018
    PubMed

    Insights

    The HIF2α antagonist PT2385 showed promise in treating advanced kidney cancer. It achieved responses in 14% of patients with heavily pretreated clear cell renal cell carcinoma (ccRCC).

    Area of Science:

    • Oncology
    • Molecular Biology
    • Pharmacology

    Background:

    • Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer.
    • Hypoxia-inducible factor 2-alpha (HIF2α) is a key driver in ccRCC progression.
    • Novel therapeutic targets are needed for patients with advanced or refractory disease.

    Purpose of the Study:

    • To evaluate the efficacy of PT2385, a novel HIF2α antagonist, in patients with heavily pretreated ccRCC.
    • To assess the safety and tolerability profile of PT2385 in this patient population.

    Main Methods:

    • A clinical trial was conducted involving patients with advanced ccRCC.
    • Patients received PT2385 as a treatment.
    • Response rates and adverse events were meticulously recorded.

    Main Results:

    • PT2385 demonstrated clinical activity, achieving objective responses in 14% of heavily pretreated ccRCC patients.
    • The drug was generally well-tolerated, with a manageable safety profile.

    Conclusions:

    • HIF2α inhibition with PT2385 represents a potential therapeutic strategy for advanced ccRCC.
    • Further investigation is warranted to optimize the use of PT2385 in kidney cancer treatment.

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