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Related Concept Videos

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Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
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Left ventricular hypertrophy and cognitive function: a systematic review.

C Restrepo1, S K Patel1,2, V Rethnam1

  • 1The Florey Institute of Neuroscience and Mental Health, Austin Health, Heidelberg, VIC, Australia.

Journal of Human Hypertension
|January 14, 2018
PubMed
Summary
This summary is machine-generated.

Left ventricular hypertrophy (LVH), a marker of hypertension damage, is linked to cognitive impairment. This review found LVH is associated with poorer memory and executive functions in adults over 50.

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Area of Science:

  • Cardiology
  • Neurology
  • Gerontology

Background:

  • Cognitive impairment frequently affects patients with hypertension.
  • Left ventricular hypertrophy (LVH) signifies hypertension-related organ damage and predicts cardiovascular events.
  • Existing evidence suggests LVH independently correlates with cognitive decline, even accounting for hypertension.

Purpose of the Study:

  • To systematically review studies investigating cognitive impairment in adults with LVH.
  • To identify specific cognitive domains affected by LVH.
  • To explore potential mechanisms linking LVH and cognitive dysfunction.

Main Methods:

  • Systematic literature search in Ovid MEDLINE, Ovid psycInfo, and PubMed.
  • Inclusion criteria: English language, human studies, adults aged 50+, examining LVH and cognition.
  • Nine studies met the criteria for inclusion in the review.

Main Results:

  • The majority of included studies demonstrated an association between LVH and cognitive performance.
  • Individuals with LVH generally showed lower performance on cognitive tests compared to those without LVH.
  • Memory and executive functions were identified as cognitive domains particularly vulnerable to the presence of LVH.

Conclusions:

  • LVH is associated with impaired cognitive performance, specifically affecting memory and executive functions.
  • Cerebral white matter damage, common in LVH patients, may underlie the observed cognitive dysfunction.
  • These findings highlight the impact of LVH on cognitive health, particularly in older adults.