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Updated: Feb 15, 2026
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Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
Published on: September 25, 2017
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Left ventricular hypertrophy and cognitive function: a systematic review
C Restrepo1, S K Patel1,2, V Rethnam1
1The Florey Institute of Neuroscience and Mental Health, Austin Health, Heidelberg, VIC, Australia.
Journal of Human Hypertension
|January 14, 2018
Summary
Left ventricular hypertrophy (LVH), a marker of hypertension damage, is linked to cognitive impairment. This review found LVH is associated with poorer memory and executive functions in adults over 50.
Area of Science:
- Cardiology
- Neurology
- Gerontology
Background:
- Cognitive impairment frequently affects patients with hypertension.
- Left ventricular hypertrophy (LVH) signifies hypertension-related organ damage and predicts cardiovascular events.
- Existing evidence suggests LVH independently correlates with cognitive decline, even accounting for hypertension.
Purpose of the Study:
- To systematically review studies investigating cognitive impairment in adults with LVH.
- To identify specific cognitive domains affected by LVH.
- To explore potential mechanisms linking LVH and cognitive dysfunction.
Main Methods:
- Systematic literature search in Ovid MEDLINE, Ovid psycInfo, and PubMed.
- Inclusion criteria: English language, human studies, adults aged 50+, examining LVH and cognition.
- Nine studies met the criteria for inclusion in the review.
Main Results:
- The majority of included studies demonstrated an association between LVH and cognitive performance.
- Individuals with LVH generally showed lower performance on cognitive tests compared to those without LVH.
- Memory and executive functions were identified as cognitive domains particularly vulnerable to the presence of LVH.
Conclusions:
- LVH is associated with impaired cognitive performance, specifically affecting memory and executive functions.
- Cerebral white matter damage, common in LVH patients, may underlie the observed cognitive dysfunction.
- These findings highlight the impact of LVH on cognitive health, particularly in older adults.
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