Related Experiment Video
Updated: Feb 15, 2026

Cryo-Electron Tomography Remote Data Collection and Subtomogram Averaging
Published on: July 12, 2022
Asymptomatic population reference values for three knee patient-reported outcomes measures: evaluation of an
James M McLean1,2,3, Oscar Brumby-Rendell4, Ryan Lisle5
1Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada. james.mc_lean@adelaide.edu.au.
Objectives:
The aim was to assess whether the Knee Society Score, Oxford Knee Score (OKS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) were comparable in asymptomatic, healthy, individuals of different age, gender and ethnicity, across two remote continents. The purpose of this study was to establish normal population values for these scores using an electronic data collection system.
Hypothesis:
There is no difference in clinical knee scores in an asymptomatic population when comparing age, gender and ethnicity, across two remote continents.
Methods:
312 Australian and 314 Canadian citizens, aged 18-94 years, with no active knee pain, injury or pathology in the ipsilateral knee corresponding to their dominant arm, were evaluated. A knee examination was performed and participants completed an electronically administered questionnaire covering the subjective components of the knee scores. The cohorts were age- and gender-matched. Chi-square tests, Fisher's exact test and Poisson regression models were used where appropriate, to investigate the association between knee scores, age, gender, ethnicity and nationality.
Results:
There was a significant inverse relationship between age and all assessment tools. OKS recorded a significant difference between gender with females scoring on average 1% lower score. There was no significant difference between international cohorts when comparing all assessment tools.
Conclusions:
An electronic, multi-centre data collection system can be effectively utilized to assess remote international cohorts. Differences in gender, age, ethnicity and nationality should be taken into consideration when using knee scores to compare to pathological patient scores. This study has established an electronic, normal control group for future studies using the Knee society, Oxford, and KOOS knee scores.
Level Of Evidence:
Diagnostic Level II.
Related Concept Videos
Data Reporting and Recording
Chemical Shift: Internal References and Solvent Effects
The internal reference compound generally used in NMR spectroscopy is tetramethylsilane (TMS). TMS is preferred because it is chemically inert, soluble in NMR solvents, and easily removable. Also, the highly shielded methyl protons in TMS yield an intense...
Data Collection II
Data Collection I
Data Collection by Experiments
An example of the experimental method is a public...
Data Collection by Survey

