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Updated: Feb 15, 2026

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
Published on: March 17, 2010
Correction to: Scientific white paper on concentration-QTc modeling.
Christine Garnett1, Peter L Bonate2, Qianyu Dang3
1Division of Cardiovascular and Renal Products, Office of New Drugs, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. christine.garnett@fda.hhs.gov.
This article corrects a mathematical error in Equation 1 of the original publication. The revised linear mixed effects model equation is now accurately presented for clarity and reproducibility.
Area of Science:
- Statistics
- Biostatistics
Background:
- An error was identified in Equation 1 of a previously published article.
- The equation pertains to a pre-specified linear mixed effects model.
Purpose of the Study:
- To provide the corrected Equation 1.
- To ensure the accuracy of the statistical methodology presented in the article.
Main Methods:
- Correction of a mathematical equation.
- Re-presentation of the pre-specified linear mixed effects model.
Main Results:
- The corrected Equation 1 is provided.
- The accurate linear mixed effects model is now available.
Conclusions:
- The article ensures the integrity of the presented statistical model.
- Accurate mathematical formulations are crucial for scientific reproducibility.
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