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Ageing in Down's syndrome.

K E Hewitt, G Carter, J Jancar

    The British Journal of Psychiatry : the Journal of Mental Science
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Intellectual deterioration was observed in adults with Down

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    Area of Science:

    • Gerontology and Developmental Disabilities

    Background:

    • Down's syndrome is associated with an increased risk of premature aging and cognitive decline.
    • Understanding the factors contributing to cognitive changes in older adults with Down's syndrome is crucial for care.
    • Previous research has explored cognitive changes, but specific associations in older hospitalized populations require further investigation.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of intellectual deterioration in hospitalized patients over 50 with Down's syndrome.
    • To identify potential clinical and biological factors associated with this cognitive decline.

    Main Methods:

    • Psychological testing was administered to 23 hospitalized patients aged over 50 with Down's syndrome.
    • Clinical assessments were conducted to evaluate physical health, neurological signs, and dementia.

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  • Associations between intellectual deterioration and clinical factors like visual acuity, hearing loss, and blood parameters (macrocytosis) were analyzed.

    • Main Results:

    • Nine out of 23 patients (39%) showed significant intellectual deterioration.
    • This deterioration was independent of chronological age, sex, duration of hospitalization, or prior mental age.
    • Significant associations were found between intellectual deterioration and reduced visual acuity, hearing impairment, and macrocytosis.

    Conclusions:

    • A substantial proportion of older hospitalized Down's syndrome patients experience intellectual deterioration.
    • Sensory impairments (vision, hearing) and macrocytosis are associated with cognitive decline in this population.
    • These findings highlight the importance of monitoring sensory function and hematological parameters in older adults with Down's syndrome.