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Related Concept Videos

Tissues01:18

Tissues

85.9K
Cells with similar structure and function are grouped into tissues. A group of tissues with a specialized function is called an organ. There are four main types of tissue in vertebrates: epithelial, connective, muscle, and nervous.
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Tissues01:25

Tissues

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Tissues are a group of cells that share a common embryonic origin. Microscopic observation reveals that the cells in a tissue share morphological features and are arranged in an orderly pattern to perform specific functions. From an evolutionary perspective, tissues appear in more complex organisms. Although there are many types of cells in the human body, they are organized into four broad categories of tissues: epithelial, connective, muscle, and nervous. Each of these categories is...
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Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Biodiversity and Human Values01:24

Biodiversity and Human Values

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Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
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Plant Cells and Tissues02:01

Plant Cells and Tissues

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Plant tissues are collections of similar cells performing related functions. Different plant tissues will have their own specialized roles and can be combined with other tissues to form organs such as flowers, fruit, stem, and leaves. Two major types of plant tissue include meristematic and permanent tissue.
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Plant Tissue Culture02:57

Plant Tissue Culture

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Plant tissue culture is widely used in both primary and applied science. Applications range from plant development studies to functional gene studies, crop improvement, commercial micropropagation, virus elimination, and conservation of rare species.
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Related Experiment Video

Updated: Feb 15, 2026

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue
06:28

Cerenkov Luminescence Imaging of Interscapular Brown Adipose Tissue

Published on: October 7, 2014

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Marrow adipose tissue imaging in humans.

Vibha Singhal1, Miriam A Bredella2

  • 1Pediatric Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.

Bone
|January 15, 2018
PubMed
Summary

Marrow adipose tissue (MAT) impacts bone strength, with increased fat linked to bone loss. Advanced imaging techniques like MRI and CT can quantify MAT, aiding research into conditions like osteoporosis.

Keywords:
Dual energy computed tomography (DECT)Magnetic resonance imagingMarrow adipose tissue (MAT)Marrow adipose tissue compositionProton MR spectroscopy

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Area of Science:

  • Bone biology and metabolism
  • Medical imaging techniques
  • Endocrinology and metabolic diseases

Background:

  • Bone strength depends on bone mineral density (BMD), microarchitecture, and the bone marrow microenvironment.
  • Marrow adipose tissue (MAT) plays a critical role in bone loss pathogenesis, with increased adiposity observed in conditions like aging and osteoporosis.
  • Osteoblasts and adipocytes share a common mesenchymal stem cell origin, highlighting the interconnectedness of bone and fat metabolism.

Purpose of the Study:

  • To review non-invasive imaging technologies, specifically magnetic resonance imaging (MRI) and computed tomography (CT), for quantifying bone marrow adipose tissue (MAT).
  • To discuss the clinical applications of these imaging techniques in understanding the role of MAT in various patient populations.

Main Methods:

  • Review of magnetic resonance imaging (MRI) techniques including anatomic T1-weighted MRI, water-fat imaging, and proton MR spectroscopy.
  • Review of computed tomography (CT) techniques including single energy CT and dual energy CT for MAT assessment.
  • Discussion of clinical applications in patients with obesity, anorexia nervosa, and type 2 diabetes.

Main Results:

  • Advancements in imaging technology enable non-invasive quantification of MAT amount and composition.
  • Specific MRI and CT sequences are detailed for accurate MAT measurement.
  • Potential for these techniques to elucidate MAT's role in metabolic and bone diseases.

Conclusions:

  • Non-invasive imaging modalities like MRI and CT are valuable tools for assessing bone marrow adipose tissue (MAT).
  • Quantification of MAT can provide insights into bone health and disease pathogenesis.
  • Further clinical applications of these imaging techniques are expected to advance our understanding of metabolic bone diseases.