Multi-model Analysis of Diffusion-weighted Imaging of Normal Testes at 3.0 T: Preliminary Findings

This study aimed to establish diffusion quantitative parameters (apparent diffusion coefficient [ADC], DDC, α, D_app, and K_app) in normal testes at 3.0 T.

Sixty-four healthy volunteers in two age groups (A: 10-39 years; B: ≥ 40 years) underwent diffusion-weighted imaging scanning at 3.0 T. ADC₁₀₀₀, ADC₂₀₀₀, ADC₃₀₀₀, DDC, α, D_app, and K_app were calculated using the mono-exponential, stretched-exponential, and kurtosis models. The correlations between parameters and the age were analyzed. The parameters were compared between the age groups and between the right and the left testes.

The average ADC₁₀₀₀, ADC₂₀₀₀, ADC₃₀₀₀, DDC, α, D_app, and K_app values did not significantly differ between the right and the left testes (P > .05 for all). The following significant correlations were found: positive correlations between age and testicular ADC₁₀₀₀, ADC₂₀₀₀, ADC₃₀₀₀, DDC, and D_app (r = 0.516, 0.518, 0.518, 0.521, and 0.516, respectively; P < .01 for all) and negative correlations between age and testicular α and K_app (r = -0.363, -0.427, respectively; P < .01 for both). Compared to group B, in group A, ADC₁₀₀₀, ADC₂₀₀₀, ADC₃₀₀₀, DDC, and D_app were significantly lower (P < .05 for all), but α and K_app were significantly higher (P < .05 for both).

Our study demonstrated the applicability of the testicular mono-exponential, stretched-exponential, and kurtosis models. Our results can help establish a baseline for the normal testicular parameters in these diffusion models. The contralateral normal testis can serve as a suitable reference for evaluating the abnormalities of the other side. The effect of age on these parameters requires further attention.