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Chronic inflammation and sarcopenia: A regenerative cell therapy perspective
Jagadish K Chhetri1, Philipe de Souto Barreto1, Bertrand Fougère2
1Gérontopôle, Department of Geriatrics, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Experimental Gerontology
|January 15, 2018
Summary
Regenerative cell therapy may combat sarcopenia by modulating chronic inflammation in older adults. This approach offers potential to reduce age-related muscle loss, disability, and mortality.
Area of Science:
- Gerontology
- Regenerative Medicine
- Immunology
Background:
- Sarcopenia, characterized by reduced muscle mass and strength, significantly limits physical function in older adults.
- Chronic inflammation, or 'inflamm-aging,' is a key factor contributing to sarcopenia and other age-related conditions.
- Sarcopenia is linked to increased disability and mortality in the elderly population.
Purpose of the Study:
- To explore the potential of regenerative cell therapy in managing chronic inflammation associated with aging.
- To discuss strategies for modulating age-related inflammatory activation in older adults.
- To review the application of cell therapy for mitigating sarcopenia.
Main Methods:
- Literature review focusing on regenerative medicine and cell therapy.
- Analysis of the role of chronic inflammation in sarcopenia pathogenesis.
- Discussion of cell therapy's potential to modulate inflammatory pathways.
Main Results:
- Regenerative cell therapy presents promising avenues for addressing inflammatory disorders.
- Cell-based strategies may offer a novel approach to counteract inflamm-aging.
- Modulating inflammation via cell therapy could ameliorate sarcopenia.
Conclusions:
- Regenerative cell therapy holds potential for treating age-related inflammatory conditions like sarcopenia.
- Targeting chronic inflammation through cell therapy could improve health outcomes in the aging population.
- This review highlights cell therapy as a viable strategy to combat sarcopenia-related disability.
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