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Male Sexual Dysfunction and Hypogonadism Guidelines for the Aging Male

Kamran Ahmed1, Kostas Hatzimouratidis2, Asif Muneer3

  • 1MRC Centre for Transplantation, Kings College London. Urology Department, Guy's Hospital, London, UK.

European Urology Focus
|January 15, 2018
PubMed

Insights

Testosterone replacement therapy in older men may improve sexual function, muscle mass, and diabetes control. However, cardiovascular safety and prostate cancer risks require careful consideration.

Area of Science:

  • Gerontology
  • Endocrinology
  • Men's Health

Background:

  • Ageing is associated with cognitive and somatiform changes.
  • These changes are frequently linked to late-onset hypogonadism.
  • Testosterone replacement therapy (TRT) in older men is an area of ongoing research and debate.

Purpose of the Study:

  • To evaluate the symptomatic and clinical benefits of TRT in older men.
  • To address the controversies surrounding TRT, particularly cardiovascular safety and prostate cancer risk.

Main Methods:

  • This study reviews existing evidence on TRT in older men.
  • Focus is placed on outcomes related to sexual dysfunction, muscle mass, and diabetic control.
  • Controversial aspects concerning cardiovascular events and prostate cancer are examined.

Main Results:

  • Evidence suggests TRT can improve sexual dysfunction in older men.
  • TRT shows benefits in increasing muscle mass and improving diabetic control.
  • Areas of controversy regarding cardiovascular safety and prostate cancer risk persist.

Conclusions:

  • TRT offers potential benefits for older men with hypogonadism.
  • Further research is needed to fully clarify the cardiovascular and prostate cancer risks associated with TRT.
  • Careful consideration of individual patient profiles is essential when deciding on TRT.

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