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Proprotein Convertase Subtilisin/kexin type 9 Inhibition in Cardiovascular Prevention

Ali Ali1, Pierluigi Costanzo1, Angela Hoye1

  • 1Department of Academic Cardiology, University of Hull, Kingston upon Hull, United Kingdom.

Current Pharmaceutical Design
|January 16, 2018
PubMed

Insights

High LDL-C increases cardiovascular risk. While statins help, some patients need more. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors offer a new therapeutic option for managing cholesterol effectively.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Biochemistry

Background:

  • Elevated Low Density Lipoprotein cholesterol (LDL-C) is a primary risk factor for atherosclerotic cardiovascular and cerebrovascular diseases.
  • Statins effectively reduce cardiovascular events but may not achieve adequate LDL-C control in all patients, especially those with familial hypercholesterolemia.

Purpose of the Study:

  • To review the development and application of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors.
  • To highlight PCSK9 inhibitors as a novel therapeutic strategy for managing hypercholesterolemia.

Main Methods:

  • Literature review of studies on PCSK9 inhibitor development.
  • Analysis of clinical data regarding the efficacy and use of PCSK9 inhibitors.

Main Results:

  • PCSK9 inhibitors represent a significant advancement in lipid-lowering therapy.
  • This class of drugs offers an effective alternative for patients with statin-intolerant or statin-resistant hypercholesterolemia.

Conclusions:

  • PCSK9 inhibitors provide a new and effective therapeutic avenue for managing elevated LDL-C.
  • Their development addresses the unmet need for improved cholesterol control in specific patient populations, reducing cardiovascular risk.

Keywords:
CholesterolLDLPCSK9 inhibitorshypercholesterolemiaserum LDL-Cstatins.

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