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Aurora Kinase Inhibitors in Head and Neck Cancer

Guangying Qi1, Jing Liu1, Sisi Mi1

  • 1Department of Pathology and Physiopathology, Hepatobiliary Surgery, Affiliated Hospital of Guilin Medical University, 541000, China.

Current Topics in Medicinal Chemistry
|January 16, 2018
PubMed

Insights

Aurora kinases regulate cell division and are key targets in cancer therapy. New research explores Aurora kinase inhibitors, especially combined with chemotherapy, for improved cancer treatment strategies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Aurora kinases are serine/threonine kinases crucial for regulating cell division (mitosis).
  • Growing evidence highlights the significant role of Aurora kinases in the development and progression of various cancers (tumorigenesis).

Purpose of the Study:

  • To review recent research on Aurora kinases, focusing on their biological functions.
  • To examine the link between Aurora kinases and tumor progression.
  • To summarize the development and therapeutic potential of Aurora kinase inhibitors.

Main Methods:

  • Literature review of recent studies on Aurora kinases and their inhibitors.
  • Analysis of research data on Aurora kinase biological functions.
  • Examination of studies investigating the role of Aurora kinases in tumorigenesis.

Main Results:

  • Aurora kinases are increasingly recognized as critical regulators in cancer development.
  • Small-molecule inhibitors targeting Aurora kinases show promise as anti-cancer agents.
  • Combination therapy using Aurora kinase inhibitors and chemotherapy is a developing area.

Conclusions:

  • Aurora kinases represent a significant therapeutic target for novel cancer treatments.
  • The development of Aurora kinase inhibitors offers a promising avenue for oncology drug discovery.
  • Further research into combination therapies holds potential for enhancing cancer treatment efficacy.
Keywords:
Aurora kinase inhibitorAurora kinasesBiological functionHead and neck cancerMitosisTumor.

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