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Cognitive impairment in patients with psoriasis: A matched case-control study
Marco Innamorati1, Rossella M Quinto1, David Lester2
1Department of Human Sciences, European University of Rome, Rome, Italy.
Journal of Psychosomatic Research
|January 16, 2018
Summary
Psoriasis patients exhibit impaired cognitive functions, including memory and attention, and poorer quality of life. Cognitive deficits are linked to psoriasis, independent of psychological factors.
Area of Science:
- Neuroscience
- Psychology
- Dermatology
Background:
- Emerging evidence suggests a link between psoriasis and mild cognitive deficits.
- Psoriasis is a chronic inflammatory skin condition with potential systemic effects.
Purpose of the Study:
- To investigate cognitive domains (executive functions, memory, attention, language) in psoriasis patients.
- To examine the association between cognitive impairment and health-related quality of life (HRQoL) in psoriasis.
Main Methods:
- A matched case-control study involving 50 psoriasis outpatients and 50 controls.
- Neuropsychological tests assessed cognitive functions, psychopathology (anxiety, depression), alexithymia, and HRQoL.
Main Results:
- Psoriasis patients showed worse performance in most cognitive tests compared to controls.
- Patients reported higher anxiety, depression, alexithymia, and poorer HRQoL.
- Cognitive performance remained independently associated with psoriasis after controlling for psychopathology and alexithymia.
Conclusions:
- Psoriasis patients experience cognitive impairment, psychological distress, and reduced quality of life.
- Clinicians should screen for psychological symptoms and cognitive deficits impacting disease coping.
- Addressing cognitive deficits may improve patient management and well-being.
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