Cardiosuppressive effect of alpha-human atrial natriuretic polypeptide (alpha-hANP) in spontaneously hypertensive

|September 24, 1985

Abstract:

The hemodynamic effects of alpha-hANP were investigated in anesthetized WKY and SHR. Intravenous administration of alpha-hANP (30 ng/min per 100 g bw) caused a marked and rapid reduction in mean blood pressure (MBP) and cardiac index (CI) without any change in the total peripheral resistance index in both strains of rat. The reduction in MBP and CI was significantly greater in SHR than in WKY. It is suggested that SHR may have an enhanced cardiovascular response to alpha-hANP, but the detailed mechanism of such a response is not known.

Keywords:

hemodynamic response cardiac index natriuretic peptide blood pressure regulation

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Cardiosuppressive effect of alpha-human atrial natriuretic polypeptide (alpha-hANP) in spontaneously hypertensive...

Abstract:

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Cardiosuppressive effect of alpha-human atrial natriuretic polypeptide (alpha-hANP) in spontaneously hypertensive