[Impact of genetic polymorphisms on post-transplant complications]

Genetic association studies are now widely applied to various medical conditions and abnormalities. Unfortunately, it remains challenging to conduct such studies in cases that require hematopoietic stem cell transplantation (HSCT) because candidate patients usually have a complicated clinical background. In this field, a uniform cohort and well-designed protocol are critical to increasing the effectiveness of genetic association analyses, and parameters such as pre-conditioning regimen, donor source, graft versus host disease and its prophylaxis, and disease status need to be considered. Our studies thus far have revealed that focusing on the relationship between drug metabolism-associated genes and drug-induced complications after HSCT could often offset the complicated clinical background. Thus, here we describe a genetic association study focused on complications after HSCT.