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Calcified Amorphous Tumor-Induced Acute Cerebral Infarction
Yoshihiro Aizawa1, Toshiko Nakai1, Yuki Saito1
1Division of Cardiology, Department of Medicine, Nihon University School of Medicine.
International Heart Journal
|January 16, 2018
Summary
A cardiac calcified amorphous tumor (CAT) caused a stroke in a 38-year-old woman. Surgical removal and valve replacement revealed calcium build-up and tissue rupture may cause CAT formation.
Area of Science:
- Cardiology
- Neurology
- Pathology
Background:
- Cardiac calcified amorphous tumors (CATs) are rare and can lead to embolic events.
- Mitral annular calcification (MAC) is a common finding, particularly in older adults, and is associated with cardiovascular disease.
Observation:
- A 38-year-old woman presented with acute cerebral infarction.
- The infarction was linked to a cardiac calcified amorphous tumor (CAT) and associated mitral annular calcification (MAC).
Findings:
- The cardiac mass was surgically removed, and mitral valve replacement was performed.
- Pathological examination showed degenerating material in both the CAT and MAC.
- Findings suggest that calcium accumulation along the mitral annulus and subsequent fibrotic tissue rupture may initiate and drive CAT development.
Implications:
- This case highlights a potential mechanism for CAT formation related to MAC.
- Understanding this pathway could inform future diagnostic and therapeutic strategies for embolic stroke prevention.
- Further research is warranted to elucidate the precise relationship between MAC and CAT formation.
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