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Updated: Feb 15, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Colorectal polyposis and inherited colorectal cancer syndromes
Raphael M Byrne1, Vassiliki Liana Tsikitis1
1Department of Surgery, Division of GI and General Surgery, Oregon Health & Science University, Portland, OR, USA.
Abstract:
The majority of colorectal cancer (CRC) cases are sporadic, with hereditary factors contributing to approximately 35% of CRC cases. Less than 5% of CRC is associated with a known genetic syndrome. Although adenomatous polyposis syndromes, hamartomatous polyposis syndromes, and those previously classified as non-polyposis CRC syndromes are quite rare, it is important for clinicians to know the characteristics of each syndrome and to understand the differences in cancer risks between the different conditions. This information is very important when treatment and surveillance plans are formulated for each individual patient.
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