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Updated: Feb 15, 2026

Macrophage Cholesterol Depletion and Its Effect on the Phagocytosis of Cryptococcus neoformans
Published on: December 19, 2014
Adaptive Immunity to Cryptococcus neoformans Infections
Liliane Mukaremera1, Kirsten Nielsen1
1Department of Microbiology and Immunology, Medical School, University of Minnesota, 689 23rd Ave SE, Minneapolis, MN 55455, USA.
Abstract:
The Cryptococcus neoformans/Cryptococcus gattii species complex is a group of fungal pathogens with different phenotypic and genotypic diversity that cause disease in immunocompromised patients as well as in healthy individuals. The immune response resulting from the interaction between Cryptococcus and the host immune system is a key determinant of the disease outcome. The species C. neoformans causes the majority of human infections, and therefore almost all immunological studies focused on C. neoformans infections. Thus, this review presents current understanding on the role of adaptive immunity during C. neoformans infections both in humans and in animal models of disease.
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