Related Experiment Video

Updated: Feb 15, 2026

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System
14:55

Direct Intraventricular Delivery of Drugs to the Rodent Central Nervous System

Published on: May 12, 2013

61.9K

Principles of Management of Central Nervous System Infections

Sunit Singhi1, Suresh Kumar Angurana2

  • 1Division of Pediatrics, Medanta- The Medicity, Sector 38, Gurugram, Haryana, 122001, India. sunit.singhi@gmail.com.

Indian Journal of Pediatrics
|January 16, 2018
PubMed

Insights

Central nervous system (CNS) infections in children are emergencies requiring prompt diagnosis and management. Early recognition, laboratory tests, and swift antimicrobial therapy are crucial for better outcomes and reduced mortality.

Area of Science:

  • Pediatric infectious diseases
  • Pediatric neurology
  • Critical care medicine

Background:

  • Central nervous system (CNS) infections in children represent a critical medical emergency.
  • These infections are associated with significant mortality and morbidity.
  • A high index of suspicion is essential for timely diagnosis.

Purpose of the Study:

  • To outline the diagnostic approach for CNS infections in children.
  • To detail the immediate management strategies for pediatric CNS infections.
  • To emphasize the importance of protocolized care for improved outcomes.

Main Methods:

  • Clinical assessment supplemented by laboratory investigations including CSF Gram stain and cultures, blood culture, PCR on CSF, serological tests, and imaging.
  • Immediate management addressing airway, breathing, and circulation.
  • Protocolized management of raised intracranial pressure (ICP) and status epilepticus.

Main Results:

  • Common life-threatening complications include coma, seizure, raised ICP, focal deficits, shock, respiratory failure, and fluid/electrolyte abnormalities.
  • Prompt administration of appropriate antimicrobial agents based on suspected pathogens is vital.
  • Close monitoring for early detection of complications is necessary.

Conclusions:

  • Integrated clinical evaluation, laboratory workup, specific antimicrobial therapy, and supportive treatment are essential.
  • Protocolized management of CNS infections in children leads to better outcomes.
  • Multifaceted and prompt intervention is key to reducing mortality and morbidity.

Keywords:
AntibioticsEncephalitisMeningitisRaised ICPStatus epilepticusSteroids

More Related Videos

Production of Lentiviral Vectors for Transducing Cells from the Central Nervous System08:46

Production of Lentiviral Vectors for Transducing Cells from the Central Nervous System

Published on: May 24, 2012

37.0K
Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY10:28

Optical Clearing of the Mouse Central Nervous System Using Passive CLARITY

Published on: June 30, 2016

14.1K

Related Concept Videos

What is a Nervous System?01:25

What is a Nervous System?

Overview
105.4K
The Parasympathetic Nervous System01:14

The Parasympathetic Nervous System

Overview
116.0K
The Sympathetic Nervous System01:25

The Sympathetic Nervous System

Overview
104.1K
The Uncertainty Principle04:08

The Uncertainty Principle

Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
33.2K
Hardy-Weinberg Principle01:49

Hardy-Weinberg Principle

Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
76.7K
The Pauli Exclusion Principle03:06

The Pauli Exclusion Principle

The arrangement of electrons in the orbitals of an atom is called its electron configuration. We describe an electron configuration with a symbol that contains three pieces of information:
59.6K