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Insulin resistance and bone: a biological partnership
Caterina Conte1, Solomon Epstein2, Nicola Napoli3,4
1Clinical Transplant Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20163, Milan, Italy. conte.caterina@hsr.it.
Acta Diabetologica
|January 16, 2018
Summary
Type 2 diabetes (T2D) is linked to bone fragility, but the exact cause is unclear. This review explores the bidirectional relationship between bone health and insulin resistance in T2D, suggesting a biological partnership.
Area of Science:
- Endocrinology
- Bone Biology
- Metabolic Diseases
Background:
- Type 2 diabetes (T2D) is associated with increased fracture risk, indicating bone fragility.
- The primary defect in T2D is insulin resistance, which impacts various bodily functions.
- The precise mechanisms linking T2D, insulin resistance, and bone health remain incompletely understood.
Purpose of the Study:
- To review the existing experimental and clinical evidence on the relationship between bone and insulin resistance.
- To elucidate the pathogenesis of bone fragility in the context of T2D.
- To explore the potential role of bone in glucose metabolism regulation.
Main Methods:
- Literature review of experimental studies.
- Analysis of clinical evidence.
- Synthesis of data on insulin signaling in bone and bone's role in glucose metabolism.
Main Results:
- Insulin signaling pathways influence both bone formation and resorption.
- Evidence suggests that bone tissue may play a role in regulating glucose metabolism.
- A complex, bidirectional interaction exists between bone and insulin resistance.
Conclusions:
- The interplay between bone and insulin resistance in T2D is significant and warrants further investigation.
- Bone fragility in T2D may be partly explained by the effects of insulin resistance on bone metabolism.
- A mutual biological partnership between bone and insulin resistance is proposed.
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