Related Experiment Video
Updated: Feb 15, 2026

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
Published on: August 2, 2016
Design of Enzyme Micelles with Controllable Concavo-Convex Micromorphologies for Highly Enhanced Stability and
Tao Chen1, Yuanhong Xu1, Wenrong Yang2
1Center for Micro/Nano Luminescent and Electrochemical Materials, College of Materials Science and Engineering, Institute for Graphene Applied Technology Innovation, Qingdao University, Qingdao, 266071, China.
Abstract:
Concavo-convex micelles with controllable sizes and nanostructures are prepared via self-assembling polymer-enzyme (e.g., shellac enzyme) conjugates with heterogeneous polymer chains, which exhibit higher enzyme stability (300%) and bioactivity (760%) comparing with the well-defined ones. The applied amphiphilic and negatively charged copolymer, poly (methyl methacrylate)-block-poly (sodium p-styrene sulfonate), is synthesized via reversible addition-fragmentation chain transfer polymerization to modify shellac enzyme and immobilize the enzyme bioactivity inducer by covalent conjugation and electrostatic attraction, respectively. The degradation test of catechol confirms the application potential of as-prepared micelles as an efficient and economical decontaminant.
Related Concept Videos
Catalytically Perfect Enzymes
Most enzymes...
Enzymes
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
PD Controller: Design
Designing a continuous-data controller requires selecting and linking components like adders and integrators, which are fundamental in Proportional,...
PI Controller: Design
Enzymes and Activation Energy

