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Immunoengineering with biomaterials for enhanced cancer immunotherapy
Yu-Qing Xie1, Lixia Wei2, Li Tang1,2
1Institute of Bioengineering, École polytechnique fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|January 16, 2018
Summary
Biomaterials in immunoengineering enhance cancer immunotherapy by precisely modulating the immune system. This approach aims to improve treatment efficacy and reduce side effects for better patient outcomes.
Area of Science:
- Biomaterials science
- Immunology
- Oncology
- Nanomedicine
Background:
- Cancer immunotherapy has achieved significant clinical success, demonstrating durable responses across various malignancies.
- Improving immunotherapy outcomes requires precise immune system manipulation to boost anti-cancer immunity while minimizing toxicity.
Purpose of the Study:
- To review advancements in biomaterials for immunoengineering in cancer immunotherapy.
- To explore the application of biomaterials in enhancing cell-, antibody-, immunomodulator-, and gene-based immune treatments.
Main Methods:
- Literature review of recent advancements in biomaterials for immunoengineering.
- Focus on applications in various cancer immunotherapy modalities and combinations with conventional therapies.
Main Results:
- Biomaterials enable tissue- and/or cell-specific immunomodulation.
- These materials hold potential to enhance both efficacy and safety of cancer immunotherapies.
Conclusions:
- Biomaterials engineering offers promising strategies for developing next-generation cancer immunotherapies.
- Addressing challenges and opportunities in this field is crucial for future therapeutic development.
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