Related Experiment Video
Updated: Feb 15, 2026

Glass-Based Devices to Generate Drops and Emulsions
Published on: April 5, 2022
Pharmacokinetic determination and analysis of nortriptyline based on GC-MS coupled with hollow-fiber drop-to-drop
Pratik Kumar Jagtap1, Kavita Tapadia1
1Department of Chemistry, National Institute of Technology, Raipur, Chhattisgarh, 492010, India.
Aim:
A simple, sensitive and robust technique of hollow-fiber drop-to-drop solvent microextraction coupled with GC-MS has been successfully developed for the detection of antidepressant drug nortriptyline in human blood and urine samples. The recoveries of the drug from the spiked samples are found to be well within the range and appropriate to support the method.
Results:
The LOD for the drug was obtained to be 0.007, 0.009 and 0.021 μg ml-1 in deionized water, urine and blood samples of human subjects, respectively. Linearity was obtained over the concentration range of 0.5-5.0 mg l-1 in deionized water with correlation coefficient 0.99672.
Related Concept Videos
Excess Pressure Inside a Drop and a Bubble
Solvents
A...
Analysis of Population Pharmacokinetic Data
Noncompartmental Analysis: Miscellaneous Pharmacokinetic Parameters
One key aspect of the noncompartmental approach is determining a drug's total clearance. This can be done by dividing the drug dose by the area under the concentration-time curve from zero to infinity. The area under the concentration-time curve represents the drug's...
Thin-Walled Hollow Shafts
Titration in Nonaqueous Solvents

