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Drug monitoring by volumetric absorptive microsampling: method development considerations to mitigate hematocrit

Kasie Fang1, Chester L Bowen2, John F Kellie1

  • 1Bioanalysis, In-vitro/In-vivo Translation, Platform Technology & Science, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, PA 19406, USA.

Bioanalysis
|January 16, 2018
PubMed
Abstract

Keywords:
LC–MS/MSdried blood spot (DBS)hematocrit (HCT)matrix effectmicrosamplingpharmacokinetics (PK)regulated bioanalysistoxicokinetics (TK)volumetric absorptive microsampling (VAMS) device

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