Penicillin Resistance in Enterococcus faecalis: Molecular Determinants and Epidemiology
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Updated: Feb 15, 2026

A 1.5 Hour Procedure for Identification of Enterococcus Species Directly from Blood Cultures
Published on: February 10, 2011
Iwona Gawryszewska1, Waleria Hryniewicz1, Ewa Sadowy1
1Department of Molecular Microbiology National Medicines Institute, Warsaw, Poland.
Abstract:
Enterococcus faecalis plays a significant role in hospital-acquired infections (HAIs), and combination of penicillin with aminoglycoside is important in therapy of invasive HAIs. Penicillin resistance in this organism is due to modification of the drug target, penicillin-binding protein (PBP5), its overproduction and expression of β-lactamase. Although rare, this phenotype is often associated with multi-resistant high-risk enterococcal clonal complexes (HiRECCs), such as CC2 and CC9 which may promote its spread in the near future.
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