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Predictive value of metabolic syndrome definitions in patients with myocardial infarction with ST segment elevation -

Milan Branko Lovic1, Lidija Savic2, Dragan Matic2

  • 1a Institute for Prevention and Rehabilitation Niska Banja , Nis , Serbia.

Acta Cardiologica
|January 16, 2018
PubMed

Insights

Metabolic syndrome (MS) definitions predict outcomes in ST-segment elevation myocardial infarction (STEMI) patients. The NCEP-ATP III definition identified MS as an independent predictor of major adverse cardiovascular events (MACE).

Area of Science:

  • Cardiology
  • Metabolic Disorders
  • Clinical Prognosis

Background:

  • Metabolic syndrome (MS) is a cluster of conditions increasing cardiovascular risk.
  • Standardized definitions of MS are crucial for consistent prognostic assessment.

Purpose of the Study:

  • To evaluate the predictive capability of different MS definitions (AHA-NHLBI, NCEP-ATP III, IDF) on patient outcomes after ST-segment elevation myocardial infarction (STEMI).

Main Methods:

  • Prospective study of 507 STEMI patients undergoing primary percutaneous coronary intervention.
  • Patients classified as having MS or not based on three different criteria.
  • Comparison of baseline characteristics, clinical findings, and adverse cardiovascular events between groups.

Main Results:

  • Prevalence of MS varied by definition: IDF (44.38%), AHA-NHLBI (42.80%), NCEP-ATP III (37.87%).
  • Patients with MS showed higher rates of new myocardial infarction and revascularization.
  • NCEP-ATP III defined MS independently predicted Major Adverse Cardiovascular Events (MACE), but not mortality.

Conclusions:

  • The NCEP-ATP III definition of metabolic syndrome is a significant independent predictor of adverse cardiovascular events in STEMI patients.
  • Prognostic value of MS in STEMI varies depending on the diagnostic criteria used.
Abstract

Keywords:
Metabolic syndromedefinitionsmyocardial infarctionoutcomes

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