Related Experiment Video

Updated: Feb 15, 2026

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.7K

Improvement of endothelial function by pitavastatin: a meta-analysis

Niki Katsiki1, Željko Reiner2, Eugenia Tedeschi Reiner3

  • 1a Second Propedeutic Department of Internal Medicine, Medical School , Aristotle University of Thessaloniki, Hippocration Hospital , Thessaloniki , Greece.

Expert Opinion on Pharmacotherapy
|January 16, 2018
PubMed

Insights

Pitavastatin significantly improves flow-mediated dilation (FMD), a key indicator of endothelial function. This finding suggests pitavastatin therapy can enhance vascular health in patients with dyslipidemia.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Medical Statistics

Background:

  • Dyslipidemia is linked to endothelial dysfunction and elevated cardiovascular risk.
  • Pitavastatin is known to improve lipid profiles and HDL function.
  • Flow-mediated dilation (FMD) is a critical marker for endothelial health.

Purpose of the Study:

  • To evaluate the impact of pitavastatin on flow-mediated dilation (FMD).
  • To synthesize existing clinical trial data on pitavastatin's effect on endothelial function.

Main Methods:

  • Systematic review and meta-analysis of clinical trials.
  • Searched PubMed-Medline, Scopus, ISI Web of Knowledge, and Google Scholar.
  • Employed a random-effects model for quantitative data synthesis.

Main Results:

  • Included six studies with seven treatment arms.
  • Demonstrated a significant increase in FMD with pitavastatin therapy (WMD: 2.45%, 95% CI: 1.31, 3.60, p < 0.001).
  • The effect size remained robust in sensitivity analyses.

Conclusions:

  • Pitavastatin therapy significantly enhances flow-mediated dilation (FMD).
  • This suggests a beneficial effect of pitavastatin on endothelial function.
Abstract

Keywords:
Pitavastatinatherosclerosisendothelial functionflow-mediated dilationmeta-analysis

More Related Videos

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI06:26

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images SDM-PSI

Published on: November 27, 2019

77.9K
Non-invasive Assessment of Microvascular and Endothelial Function05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

16.7K

Related Concept Videos

Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.1K
Performing a Simple Data Analysis using MS-Excel Function01:17

Performing a Simple Data Analysis using MS-Excel Function

Microsoft Excel offers a suite of functions and tools ideal for statistical analysis, making it accessible to students and researchers. This article outlines fundamental Excel functions pivotal for data analysis.
SUM: This function calculates the total sum of a range of values. It's the foundation for aggregating data, essential for determining overall trends and totals in datasets.
AVERAGE: It computes the mean value of a given set of numbers, providing a quick insight into the central...
1.1K
meta-Directing Deactivators: &ndash;NO2, &ndash;CN, &ndash;CHO, &ndash;&NoBreak;CO2R, &ndash;COR, &ndash;CO2H01:13

meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H

All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.8K
Improving Translational Accuracy02:07

Improving Translational Accuracy

3.7K
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
15.1K
Functional Groups02:45

Functional Groups

Functional groups are a group of atoms with characteristic properties, which when linked to the carbon skeleton of a molecule, alter the properties of that molecule. For example, the presence of certain functional groups on a molecule will make them hydrophilic, whereas others will make them hydrophobic. These functional groups are an indispensable part of organic chemistry and important components of biological molecules, such as carbohydrates, proteins, lipids, and nucleic acids. Each...
89.7K