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Improvement of endothelial function by pitavastatin: a meta-analysis
Niki Katsiki1, Željko Reiner2, Eugenia Tedeschi Reiner3
1a Second Propedeutic Department of Internal Medicine, Medical School , Aristotle University of Thessaloniki, Hippocration Hospital , Thessaloniki , Greece.
Expert Opinion on Pharmacotherapy
|January 16, 2018
Summary
Pitavastatin significantly improves flow-mediated dilation (FMD), a key indicator of endothelial function. This finding suggests pitavastatin therapy can enhance vascular health in patients with dyslipidemia.
Area of Science:
- Cardiovascular Research
- Pharmacology
- Medical Statistics
Background:
- Dyslipidemia is linked to endothelial dysfunction and elevated cardiovascular risk.
- Pitavastatin is known to improve lipid profiles and HDL function.
- Flow-mediated dilation (FMD) is a critical marker for endothelial health.
Purpose of the Study:
- To evaluate the impact of pitavastatin on flow-mediated dilation (FMD).
- To synthesize existing clinical trial data on pitavastatin's effect on endothelial function.
Main Methods:
- Systematic review and meta-analysis of clinical trials.
- Searched PubMed-Medline, Scopus, ISI Web of Knowledge, and Google Scholar.
- Employed a random-effects model for quantitative data synthesis.
Main Results:
- Included six studies with seven treatment arms.
- Demonstrated a significant increase in FMD with pitavastatin therapy (WMD: 2.45%, 95% CI: 1.31, 3.60, p < 0.001).
- The effect size remained robust in sensitivity analyses.
Conclusions:
- Pitavastatin therapy significantly enhances flow-mediated dilation (FMD).
- This suggests a beneficial effect of pitavastatin on endothelial function.
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