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Regulation of Cancer and Cancer-Related Genes via NAD.

Tanveer Sharif1, Emma Martell2, Cathleen Dai1

  • 11 Department of Microbiology and Immunology, Dalhousie University, Halifax, Canada.

Antioxidants & Redox Signaling
|January 17, 2018
PubMed
Abstract

Insights

Nicotinamide adenine dinucleotide (NAD+) is crucial for cancer cell metabolism and survival. Targeting NAD+ synthesis offers promising anticancer strategies by sensitizing cancer cells.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Nicotinamide adenine dinucleotide (NAD+) is a vital redox cofactor in cellular metabolism.
  • NAD+ plays a critical role in regulating various cellular processes, including gene expression, DNA repair, and proliferation.
  • Dysregulation of NAD+ metabolism is implicated in numerous diseases, particularly cancers.

Purpose of the Study:

  • To review the multifaceted roles of NAD+ metabolism in cancer.
  • To summarize how NAD+ metabolism influences pathophysiological processes in cancer.
  • To explore the exploitation of NAD+ metabolism for developing effective anticancer therapies.

Main Methods:

  • Literature review of NAD+ metabolism in cancer.
  • Analysis of NAD+-mediated signaling pathways.
  • Examination of therapeutic strategies targeting NAD+ synthesis in cancer.

Main Results:

  • NAD+-mediated signaling is integral to cancer cell functions via enzymes like sirtuins and PARPs.
  • Interfering with NAD+ metabolism shows promise in sensitizing cancer cells to treatments.
  • Current strategies targeting NAD+ synthesis are under clinical investigation.

Conclusions:

  • Understanding NAD+ metabolism is key to developing novel cancer treatments.
  • Further research into NAD+-synthesizing and -utilizing biomolecules is essential.
  • Comprehensive knowledge of NAD+ pathways can unlock its full potential in cancer therapy.
Keywords:
NADcancermetabolismredox signalingsirtuins

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