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Updated: Feb 15, 2026

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.8K

Circular RNA expression in ovarian endometriosis

Licong Shen1, Yu Zhang1, Wenjun Zhou1

  • 1Department of Obstetrics & Gynecology, Xiangya Hospital, Central South University, No 87 Xiangya Road, Changsha Hunan 410008, PR China.

Epigenomics
|January 17, 2018
PubMed
Abstract

Insights

Circular RNAs (circRNAs) show altered expression in endometriosis, potentially impacting disease development. These findings highlight circRNAs as key players in endometriosis pathogenesis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Reproductive Biology

Background:

  • Circular RNAs (circRNAs) with miRNA response elements (MREs) act as competing RNA (ceRNA) regulators of gene expression.
  • Understanding circRNA roles is crucial for endometriosis research.

Purpose of the Study:

  • To identify the expression profile of circRNAs in endometriosis.
  • To investigate the potential role of circRNAs in endometriosis pathogenesis.

Main Methods:

  • Microarray analysis of ovarian endometriomas and eutopic endometrium.
  • Quantitative real-time RT-PCR validation in 24 patient samples.
  • Bioinformatic prediction of MREs, ceRNA networks, and KEGG pathways.

Main Results:

  • Identified 262 upregulated and 291 downregulated circRNAs in endometriosis.
  • Predicted 1225 MREs, a ceRNA network of 122 miRNAs and 137 mRNAs.
  • Associated these networks with nine biological pathways.

Conclusions:

  • CircRNAs are differentially expressed in endometriosis.
  • These dysregulated circRNAs may contribute to the pathogenesis of endometriosis.
Keywords:
circRNAsendometriosismiRNAs

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